Social media, Internet technologies that facilitate interaction between people, are changing how physicians interact with patients and colleagues and how patients share information with each other. Are you perplexed about what role social media should play in your practice? Dr. Andrew N. Wilner offers a guide that explores what social media are and how they can influence the practice of neurology and the treatment of multiple sclerosis patients. Then, join Dr. Jack N. Ratchford as he reviews the latest advances concerning FDA-approved disease-modifying treatments for multiple sclerosis and how this information can be used to optimize patient outcomes. He focuses on head-to-head trials of current therapies, treatment of high-risk clinically isolated syndrome, managing breakthrough disease, and individualizing patient care. Finally, Dr. Augusto A. Miravalle asks, "Are neurologists becoming immunologists online?" He addresses this question with a discussion of the basic mechanisms of action underlying selected current and experimental disease-modifying therapies, as well as the available efficacy and safety data for these drugs.