New therapies are emerging that target angiogenesis, which is critical to solid tumor growth. Over one third of all cancers diagnosed in the United States are solid tumors and despite recent advances in cancer therapy and prevention, the incidence of solid tumors continues to rise. Two new therapies were approved in 2004 that target specific molecules involved in angiogenesis. These drugs, VEGF and EGFR inhibitors, when used in combination with chemotherapy, have demonstrated activity in a number of cancer types, including colorectal and renal carcinomas.
The emergence of this new class of drugs offers healthcare practitioners and the managed care industry an opportunity to reduce the toll of cancer. This webcast on emerging concepts in angiogenesis presents highlights from the 2005 American Society of Clinical Oncology Annual Meeting. The expert faculty discusses the role of VEGF and EGFR inhibitors for patients with advanced renal cell cancer, advanced colorectal cancer, breast malignancies, and recurrent non-small cell lung cancer, as well as implications for the future of cancer therapy.
Claiborne E. Reeder, RPh, PhD
Professor of Pharmacoeconomics
College of Pharmacy
University of South Carolina
Columbia, South Carolina
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FACULTY
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Cathy Eng, MD
Assistant Professor of Medicine
Department of Gastrointestinal Medical Oncology
University of Texas M.D. Anderson Cancer Center
Houston, Texas
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Paulo M. Hoff, MD
Assistant Professor of Medicine
Deputy Chairman for Clinical Research
Department of Gastrointestinal Medical Oncology
University of Texas M.D. Anderson Cancer Center
Houston, Texas
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Roy S. Herbst, MD, PhD
Professor of Medicine
Department of Thoracic/Head and Neck Medical Oncology
University of Texas M.D. Anderson Cancer Center
Houston, Texas
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Activity Agenda
Pharmacoeconomics of Cancer Management and Role of Angiogenesis Inhibitors in the Managed Care Setting
Claiborne E. Reeder, RPh, PhD
Advances in Managing Angiogenesis in Non-Small Cell Lung Cancer (NSCLC)
Roy S. Herbst, MD, PhD
Impact of Angiogenesis Inhibitors in the Treatment of Colorectal Cancer, Renal Cell Carcinoma, and Breast Cancer
Paulo M. Hoff, MD
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Target Audience
This activity is designed for medical directors and pharmacy directors in the managed care setting who care for patients with cancer.
Activity Goal
The goal of this professional education activity is to review treatment options for patients with solid tumors.
Learning Objectives
At the completion of this activity, participants should be able to:
- Assess the implications of new angiogenesis inhibitor data for patients in the managed care sector.
- Analyze the role of angiogenesis in the pathophysiology of cancer.
- Integrate knowledge of the efficacy and safety of current and emerging angiogenesis inhibitors into strategic therapy regimens for patients with solid tumors.
- Evaluate the benefits of angiogenesis inhibitors in combination therapy regimens for your patients.
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CME Information: PHYSICIANS
Statement of Accreditation
Projects In Knowledge is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
Credit Designation
Projects In Knowledge designates this educational activity for a maximum of 1 Category 1 credit toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.
This CME activity is planned and implemented as an independent CME activity in accordance with the ACCME Essential Areas and Policies.
Successful completion for up to 1 hour of CME credit requires a passing score of 70% or higher on the posttest. Full instructions for submission are included on the posttest.
CE Information: NURSES
This activity has been approved by the American Association of Critical-Care Nurses (ACCN) for 1.0 contact hour. Provider #00012705.
Statement of Accreditation: PHARMACISTS
Projects In Knowledge is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a provider of continuing pharmacy education.

This activity has been planned and implemented in accordance
with the ACPE Criteria for Quality and Interpretive Guidelines.
The ACPE Universal Program Number assigned to this program
for 1 contact hour (0.1 CEU) is 052-000-05-001-L01.
Contract for Mutual Responsibility in CME/CE
Projects In Knowledge has developed the Contract for Mutual Responsibility in CME/CE to demonstrate our commitment to providing the highest quality professional education to clinicians, and to help clinicians set educational goals to challenge and enhance their learning experience.
For more information on the Contract for Mutual Responsibility in CME/CE, please click here.
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Disclosure Information
The Disclosure Policy of Projects In Knowledge requires that presenters comply with the Updated Standards for Commercial Support. All faculty are required to disclose any personal interest or relationship they or their spouse/partner have with the supporters of this activity or any commercial interest that is discussed in their presentation. Any discussions of unlabeled/unapproved uses of drugs or devices will also be disclosed in the course materials.
For complete prescribing information on the products discussed during this CME/CE activity, please see your current Physicians' Desk Reference (PDR).
Cathy Eng, MD, has received grant/research support from Bristol-Myers Squibb Company, Novartis Pharmaceuticals Corporation, and Sanofi-Aventis; and is on the speakers bureau for Pfizer Inc.
Roy S. Herbst, MD, PhD, has received grant/research support from, is a consultant for, and is on the advisory board for AstraZeneca and Genentech, Inc.
Paulo M. Hoff, MD, has received grant/research support from Genentech, Inc, Novartis Pharmaceuticals Corporation, Roche Pharmaceuticals, and Sanofi-Aventis Inc.
Claiborne E. Reeder, RPh, PhD, is on the speakers bureau for AstraZeneca and Pfizer Inc; is on advisory boards for Applied Health Outcomes and AstraZeneca; and is a stockholder with Amylin, GlaxoSmithKline, Merck & Co, Inc, and Pfizer Inc.
Peer Reviewer has disclosed no significant relationships.
Conflicts of interest are thoroughly vetted by the Executive Committee of Projects In Knowledge. All conflicts are resolved prior to the beginning of the activity by the Trust In Knowledge peer review process.
There may be discussion of unlabeled/unapproved uses of drugs or devices in this activity.
The opinions expressed in this activity are those of the faculty and do not necessarily reflect those of Projects In Knowledge.
This CME/CE activity is provided by Projects In Knowledge solely as an educational service. Specific patient care decisions are the responsibility of the physician caring for the patient.
This independent CME/CE activity is supported by an educational grant from Genentech, Inc.
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